Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | CTSL | P07711 | 1/20 | 0.68 |
| ▸ | PTPRC | P08575 | 1/20 | 0.68 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.68 |
| ▸ | CTSS | P25774 | 1/20 | 0.68 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.68 |
| ▸ | ABCC9 | O60706 | 10/20 | 0.64 |
| ▸ | ABCC8 | Q09428 | 10/20 | 0.64 |
| ▸ | KCNJ11 | Q14654 | 10/20 | 0.64 |
| ▸ | KCNJ8 | Q15842 | 10/20 | 0.64 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832380 | 0.97 | ABCC9 (0.67) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL22336181 | 0.87 | PTPRC (0.74) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL22336214 | 0.87 | PTPRC (0.74) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL7821425 | 0.87 | ABCC9 (0.53) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL22321739 | 0.84 | PTPRC (0.94) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL22336063 | 0.84 | PTPRC (0.68) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL29538970 | 0.84 | PTPRC (0.94) | LCKCTSLPTPRCPTPN2PTPN1 | |
| SCHEMBL7833294 | 0.84 | NPC1 (0.55) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7829732 | 0.84 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL22336186 | 0.83 | PTPRC (0.76) | LCKCTSLPTPRCPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-5726325-A | FOR TREATING URINARY INCONTINENCE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |