Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842145 | 1.00 | MAPT (0.57) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7842901 | 0.95 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7840997 | 0.95 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7847022 | 0.91 | PTGS2 (0.60) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7843109 | 0.91 | PTGS2 (0.60) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7840988 | 0.90 | PTGS2 (0.55) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7842622 | 0.90 | PTGS2 (0.55) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7832857 | 0.90 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2KMT2AKDM4ENPC1 | |
| SCHEMBL7843934 | 0.90 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2KMT2AKDM4ENPC1 | |
| SCHEMBL7834435 | 0.88 | PTGS2 (0.49) | MAPTSMN1; SMN2PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |