Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | FBP1 | P09467 | 11/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbutamide SCHEMBL4078762 | 0.86 | ALDH1A1 (0.76) | CYP2C9ALDH1A1LMNATSHRALB | |
| Carbutamide SCHEMBL49231 | 0.86 | ALDH1A1 (0.76) | CYP2C9ALDH1A1LMNATSHRALB | |
| Carbutamide SCHEMBL7615910 | 0.78 | ALDH1A1 (0.78) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL15918 | 0.77 | ALDH1A1 (1.00) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL1536920 | 0.77 | ALDH1A1 (1.00) | CYP2C9ALDH1A1LMNATSHRALB | |
| SCHEMBL8672470 | 0.76 | ALDH1A1 (0.91) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL11356450 | 0.76 | ALDH1A1 (0.97) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL4367531 | 0.76 | ALDH1A1 (0.97) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL11357518 | 0.76 | ALDH1A1 (0.97) | CYP2C9ALDH1A1LMNATSHRALB | |
| Tolbutamide SCHEMBL140363 | 0.76 | ALDH1A1 (0.97) | CYP2C9ALDH1A1LMNATSHRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946556-A4 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | LILLY CO ELI (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0946556-A1 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027093-A1 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |