Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989074 | 0.84 | TSHR (0.65) | TSHRKMT2ABRD4EEF2KSLC6A2 | |
| SCHEMBL30746803 | 0.84 | TSHR (0.65) | TSHRKMT2ABRD4EEF2KSLC6A2 | |
| SCHEMBL9800237 | 0.80 | KMT2A (0.69) | TSHRKMT2ASRD5A1BRD4DDB1 | |
| SCHEMBL14075302 | 0.79 | NOTUM (0.42) | SRD5A1BRD4SLC6A2SLC6A4 | |
| SCHEMBL19953763 | 0.77 | HDAC4 (0.42) | KMT2ASRD5A1BRD4 | |
| SCHEMBL31092699 | 0.74 | KMT2A (0.51) | TSHRKMT2ABRD4EEF2KSLC6A2 | |
| SCHEMBL29960634 | 0.74 | SRD5A1 (0.38) | KMT2ASRD5A1BRD4SLC6A2SLC6A4 | |
| SCHEMBL29249863 | 0.74 | KMT2A (0.51) | TSHRKMT2ABRD4EEF2KSLC6A2 | |
| SCHEMBL6301387 | 0.73 | TSHR (0.46) | TSHRKMT2AEEF2KSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL29960427 | 0.73 | SRD5A1 (0.38) | SRD5A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089977-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067219-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |