Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | TK1 | P04183 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996660 | 0.87 | HPGD (1.00) | HPGDMAPK1TK1 | |
| SCHEMBL5124587 | 0.82 | HPGD (0.69) | HPGDMAPK1 | |
| SCHEMBL5117221 | 0.82 | HPGD (0.74) | HPGDMAPK1 | |
| SCHEMBL30023533 | 0.76 | MAPK1 (1.00) | HPGDMAPK1TK1 | |
| SCHEMBL5126504 | 0.75 | HPGD (0.62) | HPGDMAPK1 | |
| SCHEMBL7821340 | 0.74 | HPGD (0.69) | HPGDMAPK1 | |
| SCHEMBL5126430 | 0.74 | HPGD (0.74) | HPGDMAPK1 | |
| SCHEMBL7832167 | 0.74 | MAPK1 (0.88) | HPGDMAPK1TK1 | |
| SCHEMBL10118582 | 0.74 | HPGD (0.60) | HPGDMAPK1TK1 | |
| SCHEMBL6722443 | 0.73 | HPGD (0.68) | HPGDMAPK1TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |