Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 13/20 | 0.55 |
| ▸ | FOLR1 | P15328 | 3/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.43 |
| ▸ | FPGS | Q05932 | 2/20 | 0.42 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.37 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899009 | 0.95 | GART (0.61) | GARTFOLR1ATICSOSTMTHFD1 | |
| SCHEMBL6899022 | 0.95 | GART (0.61) | GARTFOLR1ATICSOSTMTHFD1 | |
| SCHEMBL6900347 | 0.95 | GART (0.61) | GARTFOLR1ATICSOSTMTHFD1 | |
| Pelitrexol SCHEMBL26910492 | 0.83 | GART (0.74) | GARTFOLR1ATICSOSTMTHFD1 | |
| Pelitrexol SCHEMBL13927981 | 0.83 | GART (0.74) | GARTFOLR1ATICSOSTMTHFD1 | |
| Pelitrexol SCHEMBL13916067 | 0.83 | GART (0.74) | GARTFOLR1ATICSOSTMTHFD1 | |
| SCHEMBL6900553 | 0.82 | GART (0.47) | GARTFOLR1ATIC | |
| SCHEMBL7145433 | 0.79 | GART (0.80) | GARTFOLR1ATICSOSTMTHFD1 | |
| SCHEMBL7745908 | 0.73 | GART (0.75) | GARTFOLR1ATIC | |
| SCHEMBL8537889 | 0.72 | GART (0.63) | GARTFOLR1ATICMTHFD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773943-B1 | COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS | AGOURON PHARMA (US) | 2001-09-26 | — | — | EP | claimed |