Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 11/20 | 0.63 |
| ▸ | FOLR1 | P15328 | 3/20 | 0.63 |
| ▸ | ATIC | P31939 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145433 | 0.87 | GART (0.80) | GARTFOLR1ATICMTHFD1 | |
| SCHEMBL7818728 | 0.81 | GART (0.73) | GARTFOLR1ATIC | |
| SCHEMBL6996839 | 0.80 | GART (0.66) | GARTFOLR1ATICMAPK1 | |
| SCHEMBL6991867 | 0.77 | GART (0.72) | GARTFOLR1ATIC | |
| SCHEMBL6993317 | 0.77 | GART (0.72) | GARTFOLR1ATIC | |
| SCHEMBL7799132 | 0.75 | GART (0.61) | GARTFOLR1 | |
| SCHEMBL6897950 | 0.73 | GART (0.36) | GARTFOLR1 | |
| SCHEMBL6900347 | 0.72 | GART (0.61) | GARTFOLR1ATICMTHFD1 | |
| SCHEMBL7834566 | 0.72 | GART (0.55) | GARTFOLR1ATICMTHFD1 | |
| SCHEMBL7061251 | 0.69 | GART (0.61) | GARTFOLR1ATICMTHFD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981748-A | Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |