Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979920 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7833084 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7966693 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7836121 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7836118 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7833077 | 1.00 | POLB (0.43) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7982583 | 0.90 | CYP1A2 (0.47) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7982797 | 0.90 | CYP1A2 (0.47) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7983238 | 0.88 | POLB (0.41) | POLBHPGDCHRNA7HTTSMN1; SMN2 | |
| SCHEMBL7966771 | 0.88 | POLB (0.41) | POLBHPGDCHRNA7HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0984961-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998043971-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-08 | — | — | WO | disclosed |