Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.66 |
| ▸ | ITGAV | P06756 | 20/20 | 0.66 |
| ▸ | ITGB6 | P18564 | 12/20 | 0.66 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.56 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.56 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.50 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.50 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773624 | 0.92 | ITGB3 (0.66) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL6782965 | 0.86 | ITGB3 (0.63) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL6772515 | 0.84 | ITGB3 (0.79) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL7837139 | 0.84 | ITGB3 (0.74) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL6782048 | 0.83 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL6782575 | 0.82 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL7833937 | 0.82 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGB1ITGA2B | |
| SCHEMBL8337502 | 0.80 | ITGB3 (1.00) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL6775819 | 0.80 | ITGB3 (0.76) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL13109233 | 0.79 | ITGB3 (0.67) | ITGB3ITGAVITGB6ITGB1ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |