Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11340384 | 0.82 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL17911742 | 0.73 | KMT2A (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL14193672 | 0.71 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL2958119 | 0.71 | HPGD (0.54) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL11345308 | 0.69 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL7488560 | 0.69 | KDM4E (0.57) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL28197859 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDRXFP1CYP1A2 | |
| SCHEMBL22198972 | 0.69 | HSD17B10 (0.53) | ALDH1A1KDM4EHPGDRXFP1LMNA | |
| SCHEMBL17918807 | 0.69 | KMT2A (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL18701272 | 0.67 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EHPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |