Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DPYD | Q12882 | 1/20 | 0.38 |
| ▸ | UPP1 | Q16831 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27284697 | 0.77 | DPYD (0.37) | DPYDUPP1 | |
| SCHEMBL16174540 | 0.73 | DPYD (0.38) | TYMPDPYDGDA | |
| SCHEMBL6694829 | 0.68 | KDM4E (0.52) | KDM4EATMDPYDUPP1ALDH1A1 | |
| SCHEMBL4560425 | 0.67 | TYMP (0.56) | TYMPALDH1A1ATAD2GDA | |
| SCHEMBL1445690 | 0.67 | TYMP (0.56) | TYMPALDH1A1ATAD2GDA | |
| SCHEMBL16167222 | 0.67 | MEN1 (0.41) | DPYDALDH1A1GAA | |
| SCHEMBL10933269 | 0.66 | DAO (0.40) | KDM4EATMDPYDUPP1ALDH1A1 | |
| SCHEMBL31376425 | 0.65 | TYMP (0.54) | TYMPATMATAD2GDA | |
| SCHEMBL11900309 | 0.65 | KDM4E (0.36) | KDM4EATMUPP1ALDH1A1HPGD | |
| SCHEMBL9007002 | 0.65 | TYMP (0.43) | TYMPKDM4EALDH1A1HSD17B10ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |