SCHEMBL1445690

SCHEMBL1445690

Cc1[nH]c(=O)[nH]c(=O)c1C

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TYMP P19971 4/20 0.56
NPC1 O15118 1/20 0.42
ATAD2 Q6PL18 1/20 0.39
GDA Q9Y2T3 1/20 0.38
LMNA P02545 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
CYP3A4 P08684 1/20 0.36
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CA1 P00915 1/20 0.35
PDE3B Q13370 1/20 0.34
PDE3A Q14432 1/20 0.34
POLB P06746 1/20 0.34
ALOX15 P16050 1/20 0.33
PNP P00491 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4560425 1.00 TYMP (0.56) TYMPNPC1ATAD2GDALMNA
SCHEMBL5163518 0.74 TYMP (0.48) TYMPNPC1ATAD2GDALMNA
SCHEMBL31376425 0.74 TYMP (0.54) TYMPATAD2GDACA1PNP
SCHEMBL10021065 0.73 PDE3B (0.45) TYMPALDH1A1KMT2APDE3BPDE3A
SCHEMBL2888237 0.72 TYMP (0.52) TYMPNPC1LMNAPDE3BPDE3A
SCHEMBL4560955 0.72 TYMP (0.52) TYMPNPC1SMN1; SMN2PDE3BPDE3A
SCHEMBL4560171 0.72 TYMP (0.52) TYMPNPC1ATAD2GDALMNA
SCHEMBL2891489 0.72 TYMP (0.52) TYMPNPC1SMN1; SMN2PDE3BPDE3A
SCHEMBL13932516 0.72 TYMP (0.41) TYMPNPC1ATAD2GDALMNA
SCHEMBL4561126 0.72 TYMP (0.52) TYMPNPC1LMNAPDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
US-20220195497-A1 HYBRIDIZING all-LNA OLIGONUCLEOTIDES ROCHE DIAGNOSTICS OPERATIONS, INC. 2022-06-23 US claimed
EP-3980554-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2022-04-13 EP claimed
CN-113939599-A Hybrid all-LNA oligonucleotides 豪夫迈·罗氏有限公司 2022-01-14 CN claimed
WO-2020245377-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-12-10 WO claimed
US-9839642-B2 Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors MERCK SHARP & DOHME CORP. (US) 2017-12-12 US claimed
US-20170173035-A1 BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2017-06-22 US claimed
EP-3139918-A1 BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2017-03-15 EP claimed
WO-2015171474-A1 BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2015-11-12 WO claimed
US-7132229-B2 Photothermographic material and image forming method FUJI PHOTO FILM CO., LTD (JP) 2006-11-07 US claimed
US-20060019207-A1 Photothermographic material and image forming method FUJIFILM CORPORATION (JP) 2006-01-26 US claimed
US-12552882-B2 Polymeric disinfectants and uses thereof TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) 2026-02-17 US disclosed
EP-4237493-B1 POLYMERIC DISINFECTANTS AND USES THEREOF TECHNION RES & DEV FOUNDATION (IL) 2025-12-10 EP disclosed
US-20250361558-A1 THIRD DNA BASE PAIR SITE-SPECIFIC DNA DETECTION ILLUMINA INC (US) 2025-11-27 US disclosed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP disclosed
US-4207416-A ANTITUMOR AGENTS ENGELHARD MINERALS & CHEMICALS CORPORATION (US) 1980-06-10 US disclosed
US-4113949-A GERMICIDES PCR, INC. (US) 1978-09-12 US disclosed
US-4080324-A ANTITUMOR AGENTS ENGELHARD MINERALS & CHEMICALS CORPORATION (US) 1978-03-21 US disclosed
US-3954758-A GERMICIDES, CANCER CHEMOTHERAPY PCR, INC. (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170173035-A1 BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS MGAM, CMBL, PEPD TYMP 2346/4885NPC1 3507/4885ATAD2 2972/4885
US-12552882-B2 Polymeric disinfectants and uses thereof PIK3C3, POLR1C, CUTA TYMP 4415/4885NPC1 4776/4885ATAD2 2257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.