Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | PDE5A | O76074 | 15/20 | 0.60 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.54 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174189 | 0.90 | ADORA3 (0.61) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16106158 | 0.89 | ADORA3 (0.66) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL174830 | 0.89 | ADORA3 (0.63) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16244821 | 0.88 | ADORA3 (0.63) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL27557251 | 0.88 | ADORA3 (0.60) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL6219334 | 0.88 | ADORA3 (0.60) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913936 | 0.87 | ADORA3 (0.62) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL4939648 | 0.87 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL20682623 | 0.87 | ADORA3 (0.57) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15732812 | 0.87 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104421-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO 3,4-B]PYRIDINE | BAYER AG (DE) | 2001-06-06 | — | — | EP | disclosed |
| EP-1104421-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO 3,4-B]PYRIDINE | BAYER AG (DE) | 2001-06-06 | — | — | EP | disclosed |
| EP-1104421-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO 3,4-B]PYRIDINE | BAYER AG (DE) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000006567-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006567-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006567-A1 | 3-(4-AMINO-5-ETHYLPYRIMIDINE-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-10 | — | — | WO | disclosed |