Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379510 | 0.99 | HDAC1 (0.60) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL30420736 | 0.97 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL9805782 | 0.87 | HSD17B3 (0.49) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL9805783 | 0.86 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9AHDAC1HDAC8 | |
| SCHEMBL7230782 | 0.85 | HDAC1 (0.65) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL3431783 | 0.85 | HDAC1 (0.62) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL9805762 | 0.85 | ALDH1A1 (0.60) | ALDH1A1NPC1RAB9AHDAC1HDAC8 | |
| Naphthalene SCHEMBL28059486 | 0.84 | CYP4F2 (0.63) | SMN1; SMN2ALDH1A1GAACYP4F2CYP4A11 | |
| SCHEMBL9805774 | 0.84 | PPARG (0.53) | SMN1; SMN2NPC1RAB9ACYSLTR2CYSLTR1 | |
| SCHEMBL7831102 | 0.84 | HDAC8 (0.62) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |