Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
| ▸ | S100A4 | P26447 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22029242 | 0.86 | PTPRC (0.53) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL32677553 | 0.86 | PTPRC (0.53) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8662686 | 0.69 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL30898601 | 0.69 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1899280 | 0.68 | PTPRC (0.88) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL29566445 | 0.68 | PTPRC (0.88) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL9672807 | 0.68 | PTPRC (0.69) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL7918737 | 0.67 | MEN1 (0.52) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL2294786 | 0.67 | CYP1A2 (0.39) | KDM4EMAPK1 | |
| SCHEMBL31435352 | 0.67 | MAPK14 (0.56) | NPC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497083-B1 | HETEROCYCLIC NAPHTHOQUINONES DERIVATIVES FOR USE IN THE TREATMENT OF CANCERS INCLUDING CUSHING DISEASE | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2022-01-19 | — | — | EP | disclosed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |