Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.55 |
| ▸ | PPARA | Q07869 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831811 | 0.95 | PPARG (0.61) | PPARGFFAR1PPARAHRH3RXRA | |
| SCHEMBL6903005 | 0.91 | PPARG (0.73) | PPARGFFAR1PPARAHRH3ESRRA | |
| SCHEMBL7836370 | 0.81 | FFAR1 (0.65) | PPARGFFAR1PPARACYP3A4ESRRA | |
| SCHEMBL7833460 | 0.80 | PPARG (0.42) | PPARGFFAR1PPARARXRARARG | |
| SCHEMBL7837758 | 0.79 | PPARG (0.65) | PPARGFFAR1PPARARXRAESRRA | |
| SCHEMBL7835674 | 0.78 | FFAR1 (0.69) | PPARGFFAR1PPARAESRRA | |
| SCHEMBL6900078 | 0.77 | PPARG (0.69) | PPARGFFAR1PPARAHRH3RXRA | |
| SCHEMBL7823495 | 0.77 | PPARG (0.58) | PPARGFFAR1PPARAHRH3ESRRA | |
| SCHEMBL7835250 | 0.77 | PPARG (0.73) | PPARGFFAR1PPARAHRH3RXRA | |
| SCHEMBL1130955 | 0.77 | PPARG (0.79) | PPARGFFAR1PPARAESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676398-B1 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1022274-A1 | Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| EP-0676398-A2 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1995-10-11 | — | — | EP | disclosed |