Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218189 | 1.00 | CYP19A1 (0.37) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| SCHEMBL6218185 | 1.00 | CYP19A1 (0.37) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| SCHEMBL7835510 | 1.00 | CYP19A1 (0.37) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| SCHEMBL6218182 | 1.00 | CYP19A1 (0.37) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| Hydrochloric Acid SCHEMBL8685813 | 0.99 | CYP19A1 (0.36) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| Hydrochloric Acid SCHEMBL8903134 | 0.99 | CYP19A1 (0.36) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| Hydrochloric Acid SCHEMBL8684946 | 0.99 | CYP19A1 (0.36) | CYP19A1HTR1ADRD2DRD1HTR1B | |
| SCHEMBL7844867 | 0.88 | HTR2C (0.38) | CYP19A1HTR1AHTR2CCYP2D6ADRA2C | |
| SCHEMBL7844871 | 0.88 | HTR2C (0.38) | CYP19A1HTR1AHTR2CCYP2D6ADRA2C | |
| SCHEMBL1802487 | 0.86 | MAP3K14 (0.39) | HTR1AHTR2CADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942911-B1 | BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LAB (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |
| US-5891882-A | TREATING BENIGN PROSTATIC HYPERPLASIA OR OTHER UROLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION AND NEUROGENIC BLADDER, OR GYNECOLOGICAL SYNDROMES SUCH AS DYSMENORRHEA | ABBOTT LABORATORIES (US) | 1999-04-06 | — | — | US | disclosed |