Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844867 | 1.00 | HTR2C (0.38) | HTR2CSLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL6218185 | 0.88 | CYP19A1 (0.37) | HTR2CHTR1ACYP2D6CYP19A1ADRA2C | |
| SCHEMBL6218182 | 0.88 | CYP19A1 (0.37) | HTR2CHTR1ACYP2D6CYP19A1ADRA2C | |
| SCHEMBL7835513 | 0.88 | CYP19A1 (0.37) | HTR2CHTR1ACYP2D6CYP19A1ADRA2C | |
| SCHEMBL7835510 | 0.88 | CYP19A1 (0.37) | HTR2CHTR1ACYP2D6CYP19A1ADRA2C | |
| SCHEMBL6218189 | 0.88 | CYP19A1 (0.37) | HTR2CHTR1ACYP2D6CYP19A1ADRA2C | |
| Hydrochloric Acid SCHEMBL8684946 | 0.86 | CYP19A1 (0.36) | HTR2CHTR1ACYP19A1 | |
| Hydrochloric Acid SCHEMBL8903134 | 0.86 | CYP19A1 (0.36) | HTR2CHTR1ACYP19A1 | |
| Hydrochloric Acid SCHEMBL8685813 | 0.86 | CYP19A1 (0.36) | HTR2CHTR1ACYP19A1 | |
| SCHEMBL7845327 | 0.80 | HTR1A (0.32) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942911-B1 | BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LAB (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |