Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953165 | 0.80 | GSK3B (0.59) | GSK3BCSNK2A1KDM4EALDH1A1HPGD | |
| SCHEMBL7830317 | 0.78 | GSK3B (0.48) | GSK3BKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7835008 | 0.75 | GSK3B (0.57) | GSK3BCSNK2A1CDK2 | |
| SCHEMBL13993123 | 0.75 | CSNK2A1 (0.67) | GSK3BCSNK2A1KDM4EALDH1A1HPGD | |
| SCHEMBL6029404 | 0.72 | KDM4E (0.61) | GSK3BCSNK2A1KDM4EALDH1A1HPGD | |
| SCHEMBL7832777 | 0.68 | GSK3B (0.50) | GSK3BKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7835695 | 0.67 | GSK3B (0.48) | GSK3BKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13998521 | 0.67 | GSK3B (0.70) | GSK3BCSNK2A1KDM4EALDH1A1HPGD | |
| SCHEMBL20186414 | 0.66 | MAPT (0.46) | GSK3BCSNK2A1KDM4EALDH1A1HPGD | |
| SCHEMBL13305017 | 0.65 | CSNK2A1 (0.48) | GSK3BCSNK2A1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |