Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | CDK2 | P24941 | 10/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832356 | 0.82 | CDK2 (0.47) | GSK3BCDK2CCNE1 | |
| SCHEMBL7829217 | 0.80 | GSK3B (0.58) | GSK3BCDK2CCNE1 | |
| SCHEMBL7833604 | 0.78 | CDK2 (0.47) | GSK3BCDK2CCNE1 | |
| SCHEMBL7835602 | 0.75 | GSK3B (0.48) | GSK3BCDK2CSNK2A1 | |
| SCHEMBL8571772 | 0.75 | GSK3B (0.42) | GSK3BCDK2CCNE1 | |
| SCHEMBL7835136 | 0.74 | CDK2 (0.41) | GSK3BCDK2CCNE1 | |
| SCHEMBL7829710 | 0.74 | GSK3B (0.41) | GSK3BCDK2CCNE1 | |
| SCHEMBL7835614 | 0.74 | CDK2 (0.41) | GSK3BCDK2CCNE1 | |
| SCHEMBL12953165 | 0.74 | GSK3B (0.59) | GSK3BCDK2CSNK2A1 | |
| SCHEMBL13993123 | 0.74 | CSNK2A1 (0.67) | GSK3BCDK2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |