Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.68 |
| ▸ | DRD3 | P35462 | 17/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836389 | 1.00 | DRD2 (0.68) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL7847824 | 0.93 | DRD2 (0.65) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL7847826 | 0.93 | DRD2 (0.65) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL7846662 | 0.92 | DRD2 (0.64) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL7846664 | 0.92 | DRD2 (0.64) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL8387283 | 0.90 | DRD2 (0.71) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL8319525 | 0.89 | DRD2 (0.69) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8685275 | 0.88 | DRD2 (0.68) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8902639 | 0.88 | DRD2 (0.68) | DRD2DRD3HTR1AHTR2BSIGMAR1 | |
| SCHEMBL8386561 | 0.86 | DRD2 (0.65) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942911-B1 | BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LAB (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |
| US-5891882-A | TREATING BENIGN PROSTATIC HYPERPLASIA OR OTHER UROLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION AND NEUROGENIC BLADDER, OR GYNECOLOGICAL SYNDROMES SUCH AS DYSMENORRHEA | ABBOTT LABORATORIES (US) | 1999-04-06 | — | — | US | disclosed |