Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420110 | 0.98 | MAOA (0.41) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL9209 | 0.98 | MAOA (0.41) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL29434883 | 0.98 | MAOA (0.41) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL7197365 | 0.98 | MAOA (0.41) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL4860431 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 | |
| Water SCHEMBL1552056 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL39996 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL2143603 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL9249037 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 | |
| SCHEMBL11161478 | 0.95 | MAOA (0.39) | MAOAMAOBLMNACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891063-B1 | BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2012-07-25 | — | — | EP | disclosed |
| EP-0747374-B1 | Sulfonamido substituted benzopyran potassium channel activators | BRISTOL MYERS SQUIBB CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0747374-A1 | Sulfonamido substituted benzopyran potassium channel activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |