Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 18/20 | 1.00 |
| ▸ | MPO | P05164 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846504 | 0.88 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7503943 | 0.84 | HTR1A (0.73) | HTR1ASLC6A4MPO | |
| SCHEMBL7844899 | 0.84 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL7837922 | 0.82 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL7843603 | 0.81 | HTR1A (0.96) | HTR1ASLC6A4 | |
| SCHEMBL7845019 | 0.81 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7840648 | 0.81 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7848371 | 0.81 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7846230 | 0.80 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7497697 | 0.79 | HTR1A (0.65) | HTR1ASLC6A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |