Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842315 | 0.85 | ALDH1A1 (0.43) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL7999978 | 0.82 | ALDH1A1 (0.44) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL7845569 | 0.81 | ALDH1A1 (0.46) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL20259096 | 0.73 | ALDH1A1 (0.58) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL7826834 | 0.71 | ALDH1A1 (0.43) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL7836872 | 0.69 | MEN1 (0.45) | ALDH1A1KMT2AMEN1NPSR1KDM4E | |
| SCHEMBL8469938 | 0.69 | ALDH1A1 (0.63) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL20259103 | 0.66 | ABCG2 (0.52) | ALDH1A1PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL6071832 | 0.65 | CYP1A2 (0.35) | ALDH1A1KDM4EMAPTHSD17B10CYP1A2 | |
| SCHEMBL7999926 | 0.65 | MEN1 (0.50) | ALDH1A1PDE4BPDE4DKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |