Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996548 | 0.88 | HDAC3 (0.40) | HPGDMAPK1L3MBTL1TSHRATM | |
| SCHEMBL8362199 | 0.88 | HDAC3 (0.40) | HPGDMAPK1L3MBTL1TSHRATM | |
| SCHEMBL6999104 | 0.87 | DAO (0.46) | HPGDL3MBTL1KDM4EALDH1A1RAB9A | |
| SCHEMBL7836036 | 0.80 | CYP4A11 (0.44) | CSNK2A2KDRCSNK2BCSNK2A1OPRD1 | |
| SCHEMBL27869200 | 0.78 | CSNK2A2 (0.40) | CSNK2A2KDRCSNK2BCSNK2A1OPRD1 | |
| SCHEMBL16901555 | 0.76 | HPGD (0.54) | CSNK2A2KDRCSNK2BCSNK2A1HPGD | |
| SCHEMBL7835865 | 0.75 | CSNK2A2 (0.38) | CSNK2A2KDRCSNK2BCSNK2A1OPRD1 | |
| SCHEMBL7835479 | 0.74 | ALDH1A1 (0.42) | CSNK2A2KDRCSNK2BCSNK2A1OPRD1 | |
| SCHEMBL1978785 | 0.74 | CSNK2A2 (0.45) | CSNK2A2KDRCSNK2BCSNK2A1OPRD1 | |
| SCHEMBL7000933 | 0.71 | SERPINE1 (0.38) | HPGDL3MBTL1NPSR1TSHRHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773943-B1 | COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS | AGOURON PHARMA (US) | 2001-09-26 | — | — | EP | disclosed |
| US-5646141-A | THIENYLALKYLATED DERIVATIVES OF PYRIDO(2,3-D)-PYRIMIDINE, PYRIMIDO(5,4-6)-(1,4)THIAZINE OR PYRIMIDO(5,4-6)-(1,4)SELENAZINE | AGOURON PHARMACEUTICALS, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5608082-A | GARFT = THE ENZYME GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE | AGOURON PHARMACEUTICALS, INC. (US) | 1997-03-04 | — | — | US | disclosed |