Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28812724 | 0.86 | RXFP1 (0.60) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| SCHEMBL8253848 | 0.84 | RXFP1 (0.77) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| SCHEMBL7276196 | 0.81 | GAA (0.59) | KMT2AMEN1ALDH1A1TSHRHTT | |
| SCHEMBL5555223 | 0.80 | RXFP1 (0.66) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| SCHEMBL8256145 | 0.80 | RXFP1 (0.70) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| SCHEMBL30417397 | 0.78 | RXFP1 (0.68) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| SCHEMBL16026597 | 0.78 | RXFP1 (0.68) | RXFP1SIGMAR1HRH4HRH3ABCC1 | |
| SCHEMBL12522808 | 0.78 | RXFP1 (0.68) | RXFP1SIGMAR1HRH4HRH3HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL5255358 | 0.78 | RXFP1 (0.51) | RXFP1SIGMAR1ABCC1POLBALDH1A1 | |
| SCHEMBL4468180 | 0.77 | RXFP1 (0.66) | RXFP1SIGMAR1PARP1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0622361-B1 | Heterocyclic compounds as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-10-04 | — | — | EP | claimed |
| EP-0622361-B1 | Heterocyclic compounds as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-10-04 | — | — | EP | disclosed |