Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845252 | 0.83 | KDM4E (0.43) | KDM4EHRH3MAOBTAAR1ATM | |
| SCHEMBL9119960 | 0.77 | KDM4E (0.39) | KDM4EHRH3ATM | |
| SCHEMBL20921262 | 0.77 | KDM4E (0.41) | KDM4EATM | |
| SCHEMBL7840228 | 0.74 | TAAR1 (0.49) | KDM4EHRH3TAAR1ATM | |
| SCHEMBL7842188 | 0.74 | KDM4E (0.43) | KDM4EATM | |
| SCHEMBL7295534 | 0.73 | KDM4E (0.38) | KDM4EHRH3TAAR1 | |
| SCHEMBL6261909 | 0.73 | KDM4E (0.40) | KDM4EHRH3SLC6A4ATM | |
| SCHEMBL8900483 | 0.73 | ATM (0.46) | KDM4EHRH3ATM | |
| SCHEMBL7491866 | 0.73 | KDM4E (0.41) | KDM4EHRH3TAAR1ATM | |
| SCHEMBL7488048 | 0.73 | KDM4E (0.41) | KDM4EHRH3TAAR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984963-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| US-6162808-A | Compounds | ASTRAZENECA U.K. LIMITED (GB) | 2000-12-19 | — | — | US | disclosed |