Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842188 | 0.83 | KDM4E (0.43) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL9607357 | 0.81 | KDM4E (0.41) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL20921262 | 0.81 | KDM4E (0.41) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL7937331 | 0.81 | FABP4 (0.42) | KDM4EHTTLMNAMAPTIL2 | |
| SCHEMBL422793 | 0.79 | KDM4E (0.39) | KDM4EHTTLMNAMAPT | |
| SCHEMBL425368 | 0.79 | KDM4E (0.39) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL7839638 | 0.77 | KDM4E (0.37) | KDM4EATMHRH3 | |
| SCHEMBL11630461 | 0.76 | KDM4E (0.50) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL7513299 | 0.76 | KDM4E (0.44) | KDM4EHTTLMNAMAPTATM | |
| SCHEMBL954192 | 0.74 | LMNA (0.48) | KDM4EHTTLMNAMAPTIL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395827-A | Analgesic, anticonvulsant, antiepileptic and anxiolytic agents | GUILFORD PHARMACEUTICALS INC. (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1993005772-A1 | φ-[2-(PHOSPHONOALKYL)PHENYL]-2-AMINOALKANOIC ACIDS AS ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | NOVA PHARMACEUTICAL CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |