Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833920 | 0.90 | PTGS2 (0.58) | PTGS2PTGDR2MAPK14PTGS1ALDH1A1 | |
| SCHEMBL7844371 | 0.88 | PTGS2 (0.60) | PTGS2PTGDR2MAPK14PTGS1 | |
| SCHEMBL7841796 | 0.85 | PTGS2 (0.54) | PTGS2MAPK14PTGS1 | |
| SCHEMBL7847056 | 0.83 | PTGDR2 (0.48) | PTGS2PTGDR2MAPK14PTGS1 | |
| SCHEMBL7843106 | 0.81 | PTGS2 (0.57) | PTGS2PTGDR2MAPK14PTGS1MEN1 | |
| SCHEMBL7844988 | 0.80 | PTGS2 (0.52) | PTGS2MAPK14PTGS1MEN1ALDH1A1 | |
| SCHEMBL7832559 | 0.80 | MAPT (0.45) | PTGS2MAPK14PTGS1ALDH1A1MAPT | |
| SCHEMBL7832074 | 0.78 | PTGS2 (0.60) | PTGS2MAPK14MEN1ALDH1A1MAPT | |
| SCHEMBL9617496 | 0.77 | PTGS2 (0.41) | PTGS2MAPK14PTGS1ALDH1A1 | |
| SCHEMBL7832752 | 0.77 | PTGS2 (0.57) | PTGS2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |