Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.55 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.37 |
| ▸ | MGMT | P16455 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840018 | 0.82 | SRC (0.44) | CDC7DBF4LMNAMAOBNEK2 | |
| SCHEMBL7833822 | 0.82 | NEK2 (0.44) | CDC7DBF4MAOBNEK2AHR | |
| SCHEMBL7830582 | 0.79 | CDC7 (0.56) | CDC7DBF4LMNA | |
| SCHEMBL7829575 | 0.79 | MAOB (0.47) | LMNAMAOBAHRMAOAPDE3B | |
| SCHEMBL7832920 | 0.78 | CDC7 (0.61) | CDC7DBF4LMNACDK1CDK2 | |
| SCHEMBL7836815 | 0.76 | MAOB (0.43) | MAOBAHRMAOAPDE3BPDE3A | |
| SCHEMBL7840697 | 0.73 | CDC7 (0.57) | CDC7DBF4LMNACDK1CDK2 | |
| SCHEMBL7832613 | 0.73 | CDC7 (0.53) | CDC7DBF4LMNANEK2AHR | |
| SCHEMBL1404475 | 0.71 | CDC7 (1.00) | CDC7DBF4LMNACDK1CDK2 | |
| SCHEMBL7822681 | 0.70 | NEK2 (0.46) | MAOBNEK2AHRPDPK1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |
| US-5965563-A | NOVEL PURINE DERIVATIVES SUCH AS N6-(2-OXINDOL-5-YL) ADENINE, METHODS OF SYNTHESIZING THEM; USE AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-10-12 | — | — | US | claimed |
| CN-1168138-A | Aryl and heteroaryl purine compounds | PHARMACIA & UPJOHN SPA (IT) | 1997-12-17 | — | — | CN | claimed |
| EP-0802914-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-10-29 | — | — | EP | claimed |
| WO-1997018212-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-05-22 | — | — | WO | claimed |
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | disclosed |
| US-5965563-A | NOVEL PURINE DERIVATIVES SUCH AS N6-(2-OXINDOL-5-YL) ADENINE, METHODS OF SYNTHESIZING THEM; USE AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-10-12 | — | — | US | disclosed |
| CN-1168138-A | Aryl and heteroaryl purine compounds | PHARMACIA & UPJOHN SPA (IT) | 1997-12-17 | — | — | CN | disclosed |
| EP-0802914-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997018212-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-05-22 | — | — | WO | disclosed |