Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840701 | 0.82 | CDC7 (0.55) | NEK2MAOBAHRPDE3BPDE3A | |
| SCHEMBL7830582 | 0.81 | CDC7 (0.56) | ALDH1A1CDC7DBF4CYP1A2 | |
| SCHEMBL7830469 | 0.78 | CYP1A2 (0.42) | MAOBAHRPDE3BPDE3ASMYD3 | |
| SCHEMBL8930219 | 0.77 | SMYD3 (0.41) | MAOBAHRPDE3BPDE3ASMYD3 | |
| SCHEMBL7834634 | 0.77 | AKT2 (0.40) | AKT2PRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7822681 | 0.76 | NEK2 (0.46) | NEK2MAOBAHRPDE3BPDE3A | |
| SCHEMBL7832613 | 0.74 | CDC7 (0.53) | NEK2AHRPDE3BPDE3AALDH1A1 | |
| SCHEMBL7840018 | 0.74 | SRC (0.44) | NEK2MAOBAHRPDE3BPDE3A | |
| SCHEMBL7822712 | 0.74 | MAOB (0.39) | MAOBAHRPDE3BPDE3ASMYD3 | |
| SCHEMBL27487825 | 0.71 | AKT2 (0.38) | AKT2PRKACAPRKACGPRKACBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |
| US-5965563-A | NOVEL PURINE DERIVATIVES SUCH AS N6-(2-OXINDOL-5-YL) ADENINE, METHODS OF SYNTHESIZING THEM; USE AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-10-12 | — | — | US | claimed |
| CN-1168138-A | Aryl and heteroaryl purine compounds | PHARMACIA & UPJOHN SPA (IT) | 1997-12-17 | — | — | CN | claimed |
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | disclosed |
| US-5965563-A | NOVEL PURINE DERIVATIVES SUCH AS N6-(2-OXINDOL-5-YL) ADENINE, METHODS OF SYNTHESIZING THEM; USE AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-10-12 | — | — | US | disclosed |
| CN-1168138-A | Aryl and heteroaryl purine compounds | PHARMACIA & UPJOHN SPA (IT) | 1997-12-17 | — | — | CN | disclosed |
| EP-0802914-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997018212-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-05-22 | — | — | WO | disclosed |