Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 2/20 | 0.82 |
| ▸ | PRKCA | P17252 | 2/20 | 0.82 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.82 |
| ▸ | JAK2 | O60674 | 1/20 | 0.82 |
| ▸ | JAK1 | P23458 | 1/20 | 0.82 |
| ▸ | TYK2 | P29597 | 1/20 | 0.82 |
| ▸ | JAK3 | P52333 | 1/20 | 0.82 |
| ▸ | IDH1 | O75874 | 7/20 | 0.66 |
| ▸ | GSK3B | P49841 | 12/20 | 0.65 |
| ▸ | QPCT | Q16769 | 10/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841423 | 0.98 | PRKCB (0.79) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7843484 | 0.91 | JAK2 (0.88) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL29525929 | 0.90 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841474 | 0.90 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7845205 | 0.88 | PRKCB (0.94) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7832574 | 0.87 | PRKCB (0.72) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7831887 | 0.86 | JAK2 (0.88) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7846087 | 0.86 | JAK2 (0.88) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841534 | 0.85 | PRKCB (0.72) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7845024 | 0.85 | PRKCB (0.72) | PRKCBPRKCAPRKCEJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |