Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.54 |
| ▸ | BACE1 | P56817 | 4/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495770 | 0.88 | MCHR1 (0.65) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL660567 | 0.87 | MCHR1 (0.57) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8209542 | 0.86 | BACE1 (0.67) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7845062 | 0.81 | OPRK1 (0.47) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8812119 | 0.80 | MCHR1 (0.57) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7839993 | 0.77 | CHRM2 (0.47) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7703855 | 0.77 | MCHR1 (0.47) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3479520 | 0.77 | BACE1 (0.73) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3479519 | 0.77 | BACE1 (0.73) | MCHR1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7840456 | 0.76 | FNTA (0.56) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |