Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833625 | 1.00 | PTGS2 (0.60) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| SCHEMBL7844851 | 0.91 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL7846441 | 0.91 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL7844087 | 0.89 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL7841996 | 0.89 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL7844014 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7847478 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7841584 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL7840175 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL7845660 | 0.88 | PTGS2 (0.70) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |