SCHEMBL7841736

SCHEMBL7841736

O=C(O)c1ccccc1Nc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 2/20 0.85
AKR1C3 P42330 4/20 0.70
AKR1C2 P52895 4/20 0.70
PTGS1 P23219 3/20 0.70
MEN1 O00255 4/20 0.64
KMT2A Q03164 4/20 0.64
MAPT P10636 3/20 0.64
ALDH1A1 P00352 1/20 0.64
TEAD4 Q15561 1/20 0.64
ALOX15 P16050 1/20 0.62
TTR P02766 1/20 0.60
TAS2R14 Q9NYV8 4/20 0.59
PTGS2 P35354 2/20 0.59
FABP3 P05413 1/20 0.58
FABP5 Q01469 1/20 0.58
GFER P55789 1/20 0.58
NGLY1 Q96IV0 1/20 0.58
TDP1 Q9NUW8 2/20 0.57
RECQL P46063 1/20 0.57
BLM P54132 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenamic Acid SCHEMBL3657701 0.98 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL29622832 0.96 FABP4 (0.92) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL25828 0.96 FABP4 (0.92) FABP4AKR1C3AKR1C2PTGS1MEN1
SCHEMBL18109767 0.96 FABP4 (0.85) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL10800939 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL27758639 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL27646881 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL11800213 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL28520019 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1
Fenamic Acid SCHEMBL27984072 0.94 FABP4 (0.89) FABP4AKR1C3AKR1C2PTGS1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877021-B1 Process for preparing 2-anilinoacridones CIBA SC HOLDING AG (CH) 2001-05-09 EP disclosed
US-6022970-A Process for preparing 2-anilinoacridones CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-02-08 US disclosed
EP-0877021-A1 Process for preparing 2-anilinoacridones Ciba SC Holding AG (CH) 1998-11-11 EP disclosed
EP-0253276-B1 PIGMENTS OF THE QUINACRIDONEQUINONE GROUP, THEIR PREPARATION PROCESS AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1993-04-21 EP disclosed
US-4881980-A ACRIDONES INCORPORATED IN CRYSTAL LATTICE HOECHST AKTIENGESELLSCHAFT (DE) 1989-11-21 US disclosed
US-4544746-A Process for preparing 2-anilinoacridone CIBA-GEIGY CORPORATION (US) 1985-10-01 US disclosed