Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516858 | 0.91 | NR4A1 (0.54) | EGFRNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL6902866 | 0.88 | EGFR (0.58) | EGFRNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL5510308 | 0.88 | EGFR (0.58) | EGFRNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL4710089 | 0.74 | SMN1; SMN2 (0.53) | NR4A1NR4A2NR4A3SMN1; SMN2KDM4E | |
| SCHEMBL14784613 | 0.74 | RAB9A (0.44) | SMN1; SMN2KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL22664703 | 0.73 | SMN1; SMN2 (0.54) | NR4A1NR4A2NR4A3SMN1; SMN2KDM4E | |
| SCHEMBL3395533 | 0.73 | NR4A1 (0.68) | EGFRNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL14784435 | 0.72 | RAB9A (0.43) | SMN1; SMN2KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL14785148 | 0.72 | MAOB (0.45) | SMN1; SMN2KDM4EKMT2AMAOBRAB9A | |
| SCHEMBL14785037 | 0.72 | MAOB (0.59) | SMN1; SMN2KDM4EKMT2AMAOBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162196-A1 | FUSED-RING COMPOUNDS AND USE THEREOF AS DRUGS | JAPAN TOBACCO INC. (JP) | 2001-12-12 | — | — | EP | disclosed |