Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 4/20 | 0.51 |
| ▸ | FNTB | P49356 | 4/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839728 | 0.87 | FNTA (0.51) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL8438533 | 0.87 | FNTA (0.38) | FNTAFNTBPGGT1BALOX5APGAA | |
| SCHEMBL7837837 | 0.87 | FNTA (0.50) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7856913 | 0.86 | FNTA (0.61) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7839572 | 0.86 | FNTA (0.55) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7839733 | 0.83 | FNTA (0.55) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7838097 | 0.83 | FNTA (0.55) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7840054 | 0.82 | FNTA (0.49) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL7839131 | 0.82 | FNTA (0.51) | FNTAFNTBPGGT1BGAALMNA | |
| SCHEMBL29372490 | 0.82 | FNTA (0.48) | FNTAFNTBPGGT1BGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | claimed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | claimed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | claimed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |