SCHEMBL7842457

SCHEMBL7842457

CCOc1cc(Cl)cc2nc(S(=O)(=O)Nc3c(C)ccnc3F)nn12

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.32
HTT P42858 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HPGD P15428 1/20 0.32
ALPL P05186 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NMT1 P30419 1/20 0.31
P2RX7 Q99572 1/20 0.31
LMNA P02545 1/20 0.30
HTR6 P50406 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7850611 0.90 FFAR4 (0.34) HTTTSHRNMT1P2RX7LMNA
SCHEMBL7851018 0.80 TSHR (0.35) KDM4EALDH1A1TSHR
SCHEMBL7849753 0.76 HTT (0.36) KDM4EHTTHPGDALPLALDH1A1
SCHEMBL7855692 0.73 TSHR (0.32) TSHR
SCHEMBL7840638 0.72 TSHR (0.35) KDM4EALDH1A1TSHRMEN1KMT2A
SCHEMBL7853356 0.71 TSHR (0.38) KDM4EHTTALPLALDH1A1TSHR
SCHEMBL8848901 0.71 LMNA (0.34) KDM4EHTTHPGDALPLALDH1A1
SCHEMBL7857851 0.70 CCR4 (0.38) KDM4EHTTALPLTSHR
SCHEMBL7848907 0.70 MEN1 (0.37) KDM4EL3MBTL1HPGDALDH1A1MEN1
SCHEMBL7841686 0.70 TSHR (0.40) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0717743-B1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 2001-11-14 EP disclosed
EP-0972774-A2 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines Dow AgroSciences LLC (US) 2000-01-19 EP disclosed
US-5571775-A EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES DOWELANCO (US) 1996-11-05 US disclosed
EP-0717743-A1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-06-26 EP disclosed
WO-1996001826-A1 N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-01-25 WO disclosed