Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833745 | 0.97 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7843112 | 0.93 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7841750 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7842273 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7842696 | 0.92 | MAPT (0.50) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7845041 | 0.92 | KMT2A (0.48) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7846126 | 0.92 | KMT2A (0.55) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7842693 | 0.90 | KMT2A (0.50) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7839835 | 0.90 | MAPT (0.48) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 | |
| SCHEMBL7840955 | 0.89 | KMT2A (0.46) | SMN1; SMN2KMT2ANPC1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |