Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833745 | 0.93 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7842696 | 0.92 | MAPT (0.50) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7846524 | 0.92 | KMT2A (0.48) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7842483 | 0.92 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7840955 | 0.92 | KMT2A (0.46) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7843112 | 0.89 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7841750 | 0.89 | SMN1; SMN2 (0.52) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7842273 | 0.89 | SMN1; SMN2 (0.52) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7839835 | 0.88 | MAPT (0.48) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 | |
| SCHEMBL7842693 | 0.88 | KMT2A (0.50) | KMT2ASMN1; SMN2KDM4ENPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |