Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 11/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MPC2 | O95563 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532951 | 0.90 | MEN1 (0.58) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL30050392 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL8496660 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL4959 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL5672808 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL21630 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL15888838 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL5672813 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL1536757 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| Troglitazone SCHEMBL29349864 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2752422-B1 | Stereoselective synthesis of phosphorus containing actives | GILEAD PHARMASSET LLC (US) | 2017-08-16 | — | — | EP | disclosed |
| US-6313164-B1 | TO ENHANCE THE ACTIVITY OF GLUTATHIONE RECLUCTASE; FOR THERAPY AND PROPHYLAXIS OF CARTARACTS | SANKYO COMPANY, LIMITED (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-1070710-A2 | Dithiolan derivatives, their preparation and their therapeutic effect | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |
| US-6013663-A | CATARACT THERAPY OR PREVENTION | SANKYO COMPANY, LIMITED (JP) | 2000-01-11 | — | — | US | disclosed |
| EP-0869126-A1 | Dithiolan derivatives, their preparation and their therapeutic effect | Sankyo Company Limited (JP) | 1998-10-07 | — | — | EP | disclosed |