Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841083 | 0.92 | ALDH1A1 (0.38) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8394662 | 0.91 | KMT2A (0.37) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL7839102 | 0.90 | POLB (0.40) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL7839222 | 0.89 | POLB (0.36) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL29435144 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL28056 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL29371790 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29613355 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5953239 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL27118310 | 0.82 | POLB (0.46) | KITPDGFRAFGFR3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919791-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | claimed |
| EP-0850939-B1 | Ellipticine derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-05-09 | — | — | EP | disclosed |
| US-5919791-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0850939-A1 | Ellipticine derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-07-01 | — | — | EP | disclosed |