Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844766 | 0.91 | PTGS2 (0.49) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7845086 | 0.89 | PTGS2 (0.47) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7840945 | 0.89 | PTGS2 (0.47) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7842262 | 0.88 | PTGS2 (0.47) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7846162 | 0.87 | PTGS2 (0.46) | PTGS2ALOX5 | |
| SCHEMBL7845243 | 0.86 | PTGS2 (0.45) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7842019 | 0.86 | ATR (0.46) | PTGS2ALOX5 | |
| SCHEMBL7842493 | 0.86 | PTGS2 (0.45) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7832470 | 0.85 | PTGS2 (0.47) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7841887 | 0.85 | PTGS2 (0.43) | PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |