Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 5/20 | 0.42 |
| ▸ | HTR1B | P28222 | 5/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842998 | 0.84 | HTR1D (0.45) | HTR1DHTR1BCYP1A2CYP3A4HTR1A | |
| SCHEMBL7841722 | 0.80 | HTR1D (0.45) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL7844484 | 0.78 | HTR1D (0.48) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL7808829 | 0.77 | HTR1B (0.43) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL7843750 | 0.75 | HTR1B (0.46) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL628780 | 0.75 | HTR2C (0.66) | ALDH1A1ADRB2HTR2CIDO1 | |
| SCHEMBL7832558 | 0.74 | HTR1D (0.44) | HTR1DHTR1BHTR1ASLC6A4IDO1 | |
| SCHEMBL2217699 | 0.73 | SLC6A4 (0.56) | IKBKBHTR1DHTR1BCYP1A2CYP3A4 | |
| SCHEMBL5793597 | 0.73 | SLC6A4 (0.56) | OPRM1OPRK1OPRL1HTR1BCYP2C19 | |
| SCHEMBL6634183 | 0.73 | SLC6A4 (0.56) | OPRM1OPRK1OPRL1IKBKBHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |