Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.45 |
| ▸ | HTR1B | P28222 | 10/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844484 | 0.90 | HTR1D (0.48) | HTR1DHTR1BHTR1AIDO1NMT2 | |
| SCHEMBL7843830 | 0.89 | DRD2 (0.43) | IDO1SLC6A4 | |
| SCHEMBL7842998 | 0.83 | HTR1D (0.45) | HTR1DHTR1BHTR1AIDO1SLC6A4 | |
| SCHEMBL7808829 | 0.83 | HTR1B (0.43) | HTR1DHTR1BHTR1AIDO1OPRM1 | |
| SCHEMBL5793597 | 0.82 | SLC6A4 (0.56) | HTR1BHTR1AIDO1OPRM1OPRK1 | |
| SCHEMBL7843750 | 0.81 | HTR1B (0.46) | HTR1DHTR1BHTR1AIDO1OPRM1 | |
| SCHEMBL7842576 | 0.80 | OPRM1 (0.47) | HTR1DHTR1BHTR1AIDO1OPRM1 | |
| Ethylene SCHEMBL6638987 | 0.80 | SLC6A4 (0.54) | HTR1BHTR1AIDO1OPRM1OPRK1 | |
| SCHEMBL7832558 | 0.79 | HTR1D (0.44) | HTR1DHTR1BHTR1AIDO1SLC6A4 | |
| SCHEMBL2217699 | 0.79 | SLC6A4 (0.56) | HTR1DHTR1BHTR1AIDO1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |