Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844794 | 0.92 | PTGS2 (0.57) | PTGS2PTGS1ADORA2AADORA1HSD11B1 | |
| SCHEMBL7840385 | 0.91 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL7842700 | 0.88 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL7842839 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7842503 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7842211 | 0.86 | PTGS2 (0.64) | PTGS2PTGS1HSD11B1L3MBTL1MEN1 | |
| SCHEMBL7844790 | 0.86 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL7847356 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7845047 | 0.84 | PTGS2 (0.66) | PTGS2PTGS1HSD11B1L3MBTL1MEN1 | |
| SCHEMBL7844755 | 0.84 | PTGS2 (0.72) | PTGS2PTGS1HSD11B1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |