Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841659 | 1.00 | GPR119 (0.56) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL7841657 | 1.00 | GPR119 (0.56) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL528604 | 0.87 | GPR119 (0.55) | GPR119TACR1GRM5KMT2AMEN1 | |
| SCHEMBL18618133 | 0.87 | STS (0.52) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL2640450 | 0.87 | JAK2 (0.48) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL2640452 | 0.87 | JAK2 (0.48) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL2807246 | 0.87 | JAK2 (0.48) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL2807244 | 0.87 | JAK2 (0.48) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL2242108 | 0.87 | GPR119 (0.54) | GPR119JAK2JAK3PTK2TACR1 | |
| SCHEMBL407256 | 0.87 | GPR119 (0.54) | GPR119JAK2JAK3PTK2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |