Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852207 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8823417 | 0.82 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL7855541 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL7989345 | 0.79 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL7853463 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL7856241 | 0.79 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7857386 | 0.79 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL10738022 | 0.74 | PTGS2 (0.78) | PTGS2PTGS1MAPK11MAPK14 | |
| SCHEMBL10739840 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL10733489 | 0.73 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085845-A2 | MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2 | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| EP-0989857-A4 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | ADVANCED MEDICINE INC (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0989857-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | Advanced Medicine, Inc. (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1999063939-A2 | MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2 | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999064037-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |