Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986711 | 0.80 | TSHR (0.45) | MAPTTSHRSMN1; SMN2MAPK1NPC1 | |
| SCHEMBL10422954 | 0.79 | TSHR (0.69) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4210381 | 0.79 | SMN1; SMN2 (0.61) | MAPTTSHRSMN1; SMN2MAPK1NPC1 | |
| SCHEMBL14319677 | 0.77 | TSHR (0.69) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL6979462 | 0.76 | MAPT (0.58) | MAPTTSHRSMN1; SMN2MAPK1NPC1 | |
| SCHEMBL7353839 | 0.76 | MEN1 (0.72) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8343388 | 0.75 | NOTUM (0.83) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL29522633 | 0.75 | TSHR (0.67) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL5251752 | 0.75 | TSHR (0.67) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL711283 | 0.75 | TSHR (0.67) | MAPTTSHRSMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |