Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845250 | 1.00 | PTGS2 (0.49) | PTGS2PTGS1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7840984 | 0.91 | CCNA2 (0.51) | PTGS2PTGS1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7845012 | 0.91 | CCNA2 (0.51) | PTGS2PTGS1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7839831 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1MAPTLMNAUSP2 | |
| SCHEMBL7832235 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1MAPTLMNAUSP2 | |
| SCHEMBL7842893 | 0.89 | PTGS1 (0.52) | PTGS2PTGS1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL7846003 | 0.89 | PTGS1 (0.52) | PTGS2PTGS1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL7840988 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL7842622 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL7843934 | 0.88 | SMN1; SMN2 (0.58) | PTGS2PTGS1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |